/ Home
/ SUBMISSION

/ The BJOC
/ Diamond Open Access
/ Journal Statistics
/ Editorial Board
/ Community
/ Call for papers

/ Latest Articles
/ Most accessed
/ Thematic issues
/ Volumes
/ Authors

/ Alerts

/ TWITTER
/ LINKEDIN
/ Mastodon
/ RSS FEED

Empty search

Article Type

Publication Date Range

Search Tips

This search combines search strings from the content search (i.e. "Full Text", "Author", "Title", "Abstract", or "Keywords") with "Article Type" and "Publication Date Range" using the AND operator.

Search Examples

aromatic	the word “aromatic”
aromatic aldehyde	the word “aromatic” OR “aldehyde”
+aromatic +aldehyde	both words “aromatic” AND “aldehyde”
+aromatic -aldehyde	the word “aromatic” but NOT “aldehyde”
“aromatic aldehyde”	the exact phrase “aromatic aldehyde”
benz*	words which begin with “benz”, such as “benzene” or “benzyl”
benz*yl	words that begin with “benz” and end with “yl”, such as “benzyl” or “benzoyl”
benzyl~	words that are close to the word “benzyl”, such as “benzoyl” (i.e., fuzzy search)

Search results

Search for "in vivo detection" in Full Text gives 2 result(s) in Beilstein Journal of Organic Chemistry.

Biomimetic molecular design tools that learn, evolve, and adapt

David A Winkler

Beilstein J. Org. Chem. 2017, 13, 1288–1302, doi:10.3762/bjoc.13.125

features in a conceptual landscape are also employed. Sparse feature detection in vivo Detection of important features in the environment is critical for the long-term sustainability of life. For example, the roughly 100 million photoreceptors in a human retina cannot not directly transmit a picture to the

PDF

Graphical Abstract

Figure 1: Hypothesized evolution of ‘life’ and ‘intelligence’.

Jump to Figure 1

Figure 2: Structure of maitotoxin, one of the most complex natural products ever tackled by total synthesis. ...

Jump to Figure 2

Figure 3: Hypothesis-driven closed-loop learning rationale for Adam and Eve. Hypothesis-driven experimentatio...

Jump to Figure 3

Figure 4: Traditional backpropagation neural network machine learning algorithm.

Jump to Figure 4

Figure 5: Comparison of architectures of shallow (non-deep) and deep neural networks. Adapted with permission...

Jump to Figure 5

Jump to Figure 6

Figure 7: A high-throughput-materials synthesis and characterization facility RAMP, (Rapid Automated Material...

Jump to Figure 7

Figure 8: An interactive procedure to design and 3D print bespoke reaction ware to optimization yield and pur...

Jump to Figure 8

Figure 9: (Top) Photograph of a small-molecule synthesizer comprised of three modules for deprotection, coupl...

Jump to Figure 9

Figure 10: An example of a composition-based descriptor vector that could be used to model or evolve materials...

Jump to Figure 10

Figure 11: Example of a simple elitism (copy unchanged), crossover, and point mutation operations acting on th...

Jump to Figure 11

Figure 12: A simple example of a two-dimensional fitness functions. The lines represent different evolutionary...

Jump to Figure 12

Figure 13: Robotic synthesis and testing of populations of pathogen-resistant polymers evolved by a combinatio...

Jump to Figure 13

Figure 14: Net deliverable energy as a function of porous material void fraction at 77 K cycling between 100 a...

Jump to Figure 14

Album

Review

Published 29 Jun 2017

Full text

Amyloid-β probes: Review of structure–activity and brain-kinetics relationships

Todd J. Eckroat,
Abdelrahman S. Mayhoub and
Sylvie Garneau-Tsodikova

Beilstein J. Org. Chem. 2013, 9, 1012–1044, doi:10.3762/bjoc.9.116

relationships with regards to affinity for target and brain kinetics. Several probes discussed herein show particularly promising results and will be of immense value moving forward in the fight against AD. Keywords: Alzheimer’s disease; in vivo detection; near-infrared fluorescence probes; PET/SPECT imaging

PDF

Graphical Abstract

Figure 1: Structures of A. dyes originally used to stain Aβ and B. newer scaffolds explored for the developme...

Jump to Figure 1

Scheme 1: General synthetic strategies (Gs) used to introduce A. ¹⁸F, B. ¹¹C, C. ^99mTc/Re, and D. ¹²³I and ¹²⁵...

Jump to Scheme 1

Scheme 2: A. Structures of radiolabeled chalcone analogues discussed. B.–D. Synthetic schemes for the prepara...

Jump to Scheme 2

Scheme 3: A. Structures of the radiolabeled flavone and aurone analogues discussed. B. Synthetic scheme for t...

Jump to Scheme 3

Scheme 4: A. Structures of the radiolabeled stilbene analogues discussed. B. Synthetic scheme for the prepara...

Jump to Scheme 4

Scheme 5: A. Structures of the diphenyl-1,3,4- and diphenyl-1,2,4-oxadiazoles discussed. B.,C. Synthetic sche...

Jump to Scheme 5

Figure 2: Structures of the radiolabeled benzothiazole analogues discussed.

Jump to Figure 2

Scheme 6: A.–F. Synthetic schemes for the preparation of [¹¹C]56b, [¹¹C]56c, 57, 58a,b, 61, and [¹⁸F]65a–d.

Jump to Scheme 6

Scheme 7: A. Structures of the [Re]- and [^99mTc]-labeled benzothiazole analogues discussed. B.,C. Synthetic s...

Jump to Scheme 7

Figure 3: Structures of the radiolabeled benzoxazole analogues discussed.

Jump to Figure 3

Scheme 8: A.–E. Synthetic schemes for the preparation of 94, [¹²³I]95e, 96–98.

Jump to Scheme 8

Figure 4: Structures of the radiolabeled benzofuran analogues discussed.

Jump to Figure 4

Scheme 9: A.–E. Synthetic schemes for the preparation of 121, [¹²⁵I]122a, 123a,b, 125a,b, and 126.

Jump to Scheme 9

Scheme 10: A. Structures of the radiolabeled imidazopyridine analogues discussed. B. Synthetic scheme for the ...

Jump to Scheme 10

Scheme 11: Synthetic scheme for the preparation of the benzimidazole 146.

Jump to Scheme 11

Figure 5: Structures of the quinolines discussed.

Jump to Figure 5

Scheme 12: Synthetic scheme for the preparation of the naphthalene analogues 152 and 160a,b.

Jump to Scheme 12

Scheme 13: A. Structures of the radiolabeled analogues resulting from the combination of various scaffolds. B.,...

Jump to Scheme 13

Scheme 14: A.–C. Synthetic schemes for the preparation of radiolabeled probes with unique scaffolds.

Jump to Scheme 14

Scheme 15: A. Structures of the oxazine-derived fluorescence probes discussed. B. Synthetic scheme for the pre...

Jump to Scheme 15

Figure 6: Structure of THK-265 (190).

Jump to Figure 6

Scheme 16: Synthetic scheme for the preparation of quinoxaline analogue 191.

Jump to Scheme 16

Album

Review

Published 28 May 2013

Full text

Other Beilstein-Institut Open Science Activities

/ Help / Support & Contact / Alerts / Privacy Policy / Terms & Conditions / Impressum